Studies have shown for YEARS that fructose (HFCS is not any different than any other fructose) doesn't trigger insulin production. This is why it was strongly suggested to diabetics in the 80s and 90s as the sugar source of choice.

HFCS is just a way to get fructose on a cost effective basis. Sucrose (cane sugar) is half fructose. Honey is, too. Most sweeteners conform to the 55% fructose, 45% glucose formula.